ICAD has two isoforms: a functional isoform of 45 kDa, ICAD-L/DNA fragmentation factor (DFF) 45 and a 35 kDa isoform, ICAD-S/DFF35. ICAD is the inhibitor of caspase-3-activated DNase which is a substrate that controls nuclear apoptosis. The inhibitor of caspase-3-activated DNase (ICAD) is a caspase 3 substrate that controls nuclear apoptosis. DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis. Antibodies that detect ICAD can be used in several scientific applications, including Western Blot, Immunocytochemistry, Immunoprecipitation, Immunohistochemistry and ELISA. ICAD Antibody (N1102) Catalog No Formulation Size Price (USD) N1102-100UG: 0.5 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05 sodium azide: 100 ug: 359. Antibodies should not be exposed to prolonged high temperatures. As with all antibodies care should be taken to avoid repeated freeze thaw cycles.
Although both ICAD-L and ICAD-S can bind and inhibit CAD, only ICAD-L was reported to be functional. tumor and its cleavage upon activation of apoptosis by anti-Fas antibody. ICAD has two isoforms: a functional isoform of 45kDa, ICAD-L/DNA fragmentation factor (DFF) 45 and a 35kDa isoform, ICAD-S/DFF35. Todos Medical is a commercial in vitro diagnostics company focused on developing novel, convenient tests for the early detection of COVID-19, cancer and neurodegenerative disorders. ICAD / DFF is a downstream molecule of caspases, participating in nuclear DNA. For products with volumes of 200 μl or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap.Īntibody can be stored at 4☌ for three months and at -20☌ for up to one year. ICAD is the inhibitor of caspase-3-activated DNase which is a substrate that controls nuclear apoptosis. Rabbit polyclonal ICAD antibody was raised against a peptide corresponding to amino acids 312 to 331 of mouse ICAD.Īntibody is supplied in PBS containing 0.02% sodium azide.ĭuring shipment, small volumes of antibody will occasionally become entrapped in the seal of the product vial. Cell-based Manufacturing Media Platform.
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